Medicines and Drugs to Treat Peptic Ulcers
What is an ulcer?
An ulcer is damage to the inner lining (the mucosa) of the stomach or the upper aspect of the intestine (duodenum). A bacterium, Helicobacter pylori, is the principal trigger of ulcers in this region.
Antibiotics:- Numerous combinations of antibiotics kill H. pylori. Most of the medicines are equally powerful. However, for the treatment to function, it’s vital that you comply with your doctor’s instructions precisely. Antibiotics most frequently prescribed for therapy of H. pylori incorporate amoxicillin (Amoxil, Wymox), clarithromycin (Biaxin), metronidazole (Flagyl) or tetracycline (Achromycin V). Some pharmaceutical companies package a combination of two antibiotics collectively, with an acid suppre. Drugs for decreasing acidity are utilized for peptic ulcer, gastroesophageal reflux condition (GERD-see Esophageal and Swallowing Disorders: Gastroesophageal Reflux Disease (GERD)), and many forms of gastritis. Some drugs are utilized in regimens for treating H. pylori infection. Drugs incorporate proton pump inhibitors, H2 blockers, antacids, and prostaglandins
Colloidal Bismuth or Tripotassium Dicitrato Bismuthate TDB (Trymo, Denol)
This is also employed for the exact same purpose as sucralfate. The dose is 240 mg, twice everyday, half an hour ahead of meals. It causes blackening of the stools and tongue, dizzines diarrhoea and bismuth toxicity. It detaches H pylori and kills them. So it is utilized in eradication regime also.
Eradication of H. Pylori Infection in Peptic Ulcer
H-pylori is responsible for causing chronic gastritis, dyspepsia, peptic ulcer and stomach tumor in several cases 90% circumstances of gastric and duodenal ulcers have H. pylori in their stomachs. Eradication of this organism is hard with single drug. Therefore a blend of two or three drugs is utilised.
It is a quite frequent difficulty presenting as sour eructations, heartburn and water brash. The signs and symptoms occur especially following a big meal and increase on lying down. In this disorder the acid contents of stomach rise in the lower component of food pipe (esophagus). The lower end of food pipe has a valve like mechanism to avoid reguritation of acid contents. When this valve (sphincter) becomes lax or weak, the acid burns the lining of food pipe causing erosions, ulcers and heartburns. In several instances of evening-time attacks of asthma, reflux is located to be a frequent dilemma. If untreated the food pipe is ultimately narrowed not permitting hard food to pass down (dysphagia). There is a chance of cancer development. Therefore, it should be treated vigorously.
Dosage: Omeprazole 20 mg, twice a day or lansoprazole 15 to 30 mg, daily for 4 to eight week are far better than H2 blockers (ranitidine or famotidine). These are frequently combined with prokinetic drugs. Widespread formulations are Omidom, Domstal-O (Omeprazole + Domperidone), Pentadom (Pantoprazole + Domperidone) and Zerocid (Lansoprazole + Domperidone).
Precautions: Individuals suffering from reflux esophagitis need to take light early dinner. The foot end of the bed really should be raised to present significantly relief. Weight reduction can also assist.
It forms thick frothy layer on the gastric juice and as a result prevents acid regurgitation. It is combined with antacids.